Where the Money Goes
Seeds planted by the beautiful lives of children gone too soon will continue to bloom for others
The research we invest in is lighting a path. Our seed grants have acquired follow-on funding from the National Institute of Health and other organizations. Our efforts have resulted in a total of $7,850,000 going to the fight against childhood brain cancer.
$50,000 DIPG All-In Initiative/National Institute of Health
This funding optimizes promising therapeutics prior to getting to the clinic. The objective is to strengthen the rationale and improve efficiency of early clinical trials while providing clinical benefit to children with highly aggressive brain tumors by expanding valuable pre-clinical information.
$100,000 MetroHealth Medical Center, Cleveland
This grant went to funding breakthrough research regarding a family of proteins which are responsible for driving glioma cell infiltration in the brain. Thanks to Prayers From Maria seed funding, this study garnered $3.3 million in supplemental funding from the National Cancer Institute and other funders which led to the discovery of two routes of genetic manipulations that could dramatically diminish brain tumor invasion.
$200,000 Dana-Farber Cancer Institute
This funded the participation of the largest genomic analysis to date of pediatric brain tumors. This study has allowed researchers a new understanding of the nature of these tumors, which led to the development of more innovative models that helped investigators advance to testing new drugs in the laboratory.
$250,000 Melana Matson Memorial Grant
This funding was awarded to the Case Western Reserve University’s Case Comprehensive Cancer Center researchers. This grant supported the study of the use of nanotechnology to deliver more targeted and less toxic chemotherapy to brain tumors. This funding led to a newly designed nanoparticle and a $2.82 million National Institute of Health grant.
$200,000 Brooks Blackmore Memorial Grant
This funding was given to the Dana-Farber Cancer Institute for a national clinical trial to deliver the most promising therapies for patients based on their genomics. This trial’s unique nature allows for new therapies to be incorporated as they are discovered and developed to help children battle the most aggressive brain tumors.
This grant was given to the Cleveland Clinic to fund epigenetics research and develop new sets of treatments to improve the life expectancy in children with deadly brain tumors. This new research involved the identification of specific inhibitor molecules that would make radiation more effective in fighting brain cancer.
$250,000 Jax Stone Memorial Grant
This funding went to Washington University to study how sex differences in epigentics impacts the genesis of pediatric high-grade glioma. Success in this study will lead to the development of sex-specific epigenetic therapies for children with brain tumors to optimize efficacy and minimize the long-term consequences.
$80,000 Kasey Mikes Memorial Grant
The Kasey Mikes grant is the first young researcher grant. It is designed to provide desperately needed start-up-funds and to encourage top young talent to commit to a long-term focus on childhood brain cancer research. This grant was awarded to Carl Koschmann at the University of Michigan, who is studying the efficacy of new drugs with precision therapy and using new techniques to monitor the progress.
$50,000 Kari McCloskey Memorial Grant
These funds were given to the Dana-Farber Cancer Institute to continue to build on the groundbreaking findings derived from our last grant to Dana-Farber. With these funds, Dana-Farber will start identifying a series of agents that attack specific aspects of the glioma’s biology by utilizing experimental drugs on the newly discovered targets from the previous trial.
$500,000 Abby Streszoff Memorial Grant
This funding goes to the Dana-Farber Cancer Institute and the University of Cincinnati, bringing together two most advanced pediatric neuro-oncology translational and clinical programs in the world. In collaboration with experts from England and Germany, this grant provides funding for a project that uses drugs to inhibit key molecules to reverse the effects of a specific mutation found in 30% of glioma tumors. The goal is to translate their findings into treating patients who need these therapies the most and study the prevention of resistance to these treatments.
*We are proud to say that only 8% goes to management/overhead!
If you would like to help us answer Maria’s prayers and help find a cure for childhood brain cancer, please consider donating to the movement.
2020 Dr. Carl Koschmann, Pediatric Neuro-Oncologist, Department of Pediatrics, University of Michigan - Recipient of Prayers From Maria Foundation Kasey Mike Memorial Young Investigator Grant
Pediatric Brain Tumor Think Tank
Prayers From Maria sponsored a Pediatric Brain Tumor Think Tank in San Francisco where 27 of the world’s top pediatric physicians, researchers, and clinicians gathered with the purpose of encouraging innovation in the field of pediatric research. Inspired by this conference, Prayers From Maria announced a $500,000 grant to be awarded to the most compelling, collaborative research initiative. For the first time, we funded a grant that would require collaboration from more than one institution to advance research and lead to new and better treatments for children battling brain tumors. This grant is named in honor of little Abby Streszoff who died of a brain tumor at the age of 6.